Sonidegib Uses, Side Effects & Warnings - Drugs.com
May 7, 2024 · Sonidegib is used to treat basal cell carcinoma (a type of skin cancer). Sonidegib is usually given when surgery or radiation cannot be used, or have been used without success. Sonidegib may also be used for purposes not listed in this medication guide.
Topical Delivery of Hedgehog Inhibitors: Current Status and ...
Nov 16, 2022 · Murine studies showed that the topical delivery of sonidegib, itraconazole, vitamin D₃ and CUR-61414 led to biological responses and tumor remission. In clinical trials, only topical patidegib and sonidegib led to at least a partial response in …
Sonidegib Advanced Patient Information - Drugs.com
Aug 22, 2024 · Sonidegib is used to treat adults with locally advanced basal cell carcinoma, a certain type of skin cancer. It is used in patients with skin cancer that has come back after surgery or cannot be treated with radiation or surgery. This …
Update on Hedgehog Pathway Inhibitor Therapy for Patients with …
Jun 12, 2022 · In 2012 the US Food and Drug Administration (FDA) approved the first oral hedgehog pathway inhibitor (HPI), vismodegib, for the treatment of advanced BCC ( 7 ). Its mechanism of action consists of inhibition of smoothened (SMO) and consequently inactivation of the hedgehog pathway.
Sonidegib: Safety and Efficacy in Treatment of Advanced Basal …
Apr 15, 2020 · Sonidegib (Odomzo ®), an oral smoothened (SMO) antagonist, is indicated for the treatment of adult patients with locally advanced basal cell carcinoma (laBCC) who present recurrence following surgery or radiation therapy, or those …
Basal Cell Carcinoma Treatment & Management - Medscape
Apr 3, 2024 · Topical 5-fluorouracil 5% cream may be used to treat small, superficial BCCs in low-risk areas. It interferes with DNA synthesis by blocking methylation of deoxyuridylic acid and...
Full article: Sonidegib, a novel smoothened inhibitor for the …
Sep 14, 2016 · Sonidegib is a novel smoothened inhibitor that was recently approved by the US Food and Drug Administration. This review focuses on BCC pathogenesis and the clinical efficacy of sonidegib for the treatment of advanced BCC.
Sonidegib: MedlinePlus Drug Information
Sonidegib is used to treat basal cell carcinoma (BCC; a type of skin cancer) in adults with cancer that has come back after surgery or radiation, or in adults that cannot be treated with surgery or radiation. Sonidegib is in a class of medications called hedgehog pathway inhibitors.
Full article: Topical hedgehog inhibitors for basal cell carcinoma: …
Mar 8, 2022 · Patidegib and itraconazole are two topical agents emerging as an alternative to oral vismodegib and sonidegib for difficult-to-treat BCCs. Topical medications have limited systemic absorption, leading to markedly improved tolerability but reduced efficacy.
Sonidegib Dosage Guide + Max Dose, Adjustments - Drugs.com
May 7, 2024 · Detailed Sonidegib dosage information for adults. Includes dosages for Basal Cell Carcinoma; plus renal, liver and dialysis adjustments.