ROS1 and Lung Cancer - American Lung Association
Oct 2, 2024 · Knowing if you have ROS1-positive lung cancer is important no matter your stage of lung cancer. However, it has the most treatment implications for advanced-stage patients with …
ROS1-Positive Lung Cancer: Symptoms, Treatment, and More
Feb 3, 2024 · What Is ROS1-Positive Lung Cancer? ROS1 positive lung cancer is an aggressive form of lung cancer that often spreads quickly. New, targeted medications can help keep this …
What is ROS1-positive in lung cancer and how is it treated? - LCFA
A ROS1-positive lung cancer, also known as a ROS1 rearrangement in lung cancer, refers to any lung cancer that tests positive for a fusion in the ROS1 gene. ROS1 rearrangements occur in …
Repotrectinib Shrinks ROS1-Positive NSCLC Tumors - NCI
Feb 16, 2024 · Treatment with repotrectinib can shrink tumors in people with advanced lung cancer whose tumors have ROS1 fusions. FDA approved the drug in 2023 as an initial or …
ROS1 in Lung Cancer: ESMO Biomarker Factsheet
ROS1 has been described as an ‘orphan’ receptor tyrosine kinase and has no known ligand. The protein product of the gene is a member of the insulin receptor family and is related to ALK. …
The Road Less Traveled: A Guide to Metastatic ROS1 -Rearranged …
Nov 19, 2020 · In this review, we focus on the management of patients with advanced NSCLC harboring a ROS1 rearrangement. We aim to provide insight into the diagnosis, treatment …
Progress of non-small-cell lung cancer with ROS1 rearrangement
ROS1 rearrangement is found in 0.9%–2.6% of people with non-small-cell lung cancers (NSCLCs). Tyrosine kinase inhibitors (TKIs) target ROS1 and can block tumor growth and …
Novel Targets in Non-Small Cell Lung Cancer: ROS1 and RET …
Jun 28, 2013 · Genetic alterations in ROS1 and RET were recently identified in NSCLC patients, and those affected appear to have unique clinical and pathologic features that may facilitate …
Importance of ROS1 gene fusions in non-small cell lung cancer
Jun 9, 2023 · Among several genetic aberrations that are actionable in non-small cell lung cancer (NSCLC), ROS1 translocations also known as gene fusion proteins, are found in only 1%-2% …
Advances and future directions in ROS1 fusion-positive lung cancer
Aug 23, 2024 · Understanding of the biology of ROS1 fusion-positive (ROS1+) non–small cell lung cancer (NSCLC) and treatment approaches has progressed immensely over the past …