Protein Synthesis Inhibitors- Definition, Examples, Inhibition, …
Aug 3, 2023 · Aminoglycosides: When aminoglycosides get their entry into the cytoplasm, inhibition of bacterial protein synthesis and mistranslation of protein occurs. They bind to the A-site of 16s rRNA with high affinity.
Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of ...
Although several inhibitors, such as blasticidin S, bactobolin A, and negamycin, have been reported to interfere with translation termination (77, 81, 118), these antibiotics also hamper other steps of protein synthesis. This makes apidaecin the first inhibitor known to be specific for the termination step of translation.
Bacterial Protein Synthesis as a Target for Antibiotic Inhibition
Protein synthesis in bacteria can be divided into four main steps: initiation, elongation, termination, and ribosome recycling. Two of these steps—initiation and elongation—are targeted by numerous antibiotics.
Protein Synthesis Inhibitors - DrugBank Online
A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
Protein Synthesis Inhibitor - an overview | ScienceDirect Topics
Protein synthesis inhibitors represent another major group of clinically useful antibacterials, such as erythromycin, tetracycline, chloramphenicol, and aminoglycosides. They selectively interact with the 70S bacterial ribosome and spare the 80S eukaryotic ribosome particle.
The different classes of antibiotics are the following: macrolides/lincosamides, aminoglycosides (the only bactericidal class in this group), tetracyclines, chloramphenicol, streptogramins and oxazolidinones.
13.2D: Inhibiting Protein Synthesis - Biology LibreTexts
Nov 23, 2024 · Protein synthesis inhibitors work at different stages of prokaryotic mRNA translation into proteins like initiation, elongation (including aminoacyl tRNA entry, proofreading, peptidyl transfer, and ribosomal translocation), and termination.
Mechanisms of Action - Protein Synthesis Inhibitors Macrolides • Broad spectrum antibioticsBroad spectrum antibiotics • Original agent: erythromycin • Azalides: azithromycin and clarithromycin – selected antimicrobial and pharmacokinetic advantages
Tetracycline - StatPearls - NCBI Bookshelf
Jun 5, 2023 · Tetracyclines classify as protein synthesis inhibitor antibiotics and are considered to be broad-spectrum. This activity reviews the indications, action, and contraindications for tetracyclines as a valuable agent in treating bacterial infections.
Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial ribo-somes and the translational machinery represent one of the major targets for antibiotics in the cell.
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