Fat causes necrosis and inflammation in parenchymal cells in …
Sep 15, 2021 · Fat accumulation causes necrosis of liver parenchymal cells at the single cell level. A Low magnification of a jet-fixed needle biopsy of a steatotic human liver. Large fat droplets with a preserved lipid content leave little room for the cytoplasms of …
parenchymal cells. However, in the more extreme accumulations, in a disease called hemochromatosis, there is an associated liver, heart and pancreatic damage. This results in liver cirrhosis, heart failure and diabetes mellitus. 24
Kidney lipid dysmetabolism and lipid droplet accumulation in …
Understanding the mechanisms linking kidney parenchymal lipid accumulation to CKD of metabolic or non-metabolic origin is challenging, owing to the tremendous variety of lipid species and their functional diversity across different parenchymal cells.
Kidney lipid dysmetabolism and lipid droplet accumulation in …
Jul 27, 2023 · In this Review, we discuss the clinical and experimental evidence of pathogenic lipid droplet (LD) accumulation in the kidney parenchyma, as well as the molecular mechanisms by which...
Fat accumulation causes necrosis of liver parenchymal cells at …
Fat accumulation causes necrosis of liver parenchymal cells at the single cell level. A Low magnification of a jet-fixed needle biopsy of a steatotic human liver. Large fat droplets with a...
Endothelial force sensing signals to parenchymal cells to regulate …
Sep 27, 2024 · The data suggest an endothelial force sensing mechanism that controls lipid regulation in parenchymal cells to modulate whole-body lipid homeostasis.
Lipid Accumulation and Chronic Kidney Disease - PMC - PubMed …
Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is detrimental to renal function.
Intracellular accumulations - New
Abnormal accumulation of triglycerides within parenchymal cells is fatty change (steatosis). Seen in liver (most common), heart, skeletal muscle, and kidney. Alcohol abuse and diabetes associated with obesity are the most common causes of fatty change in the liver.
Fat causes necrosis and inflammation in parenchymal cells in
We regularly observe the extrusion of huge fat droplets, traversing the peripheral cytoplasm of parenchymal cells, the Disse space and the endothelium. These fat droplets fill the sinusoid as a sinusoidal lipid embolus.
Lipid Accumulation and Chronic Kidney Disease - PubMed
Mar 28, 2019 · Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is detrimental to renal function.