p53 - Wikipedia
p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. [ 5 ]
Tumor suppressor p53: Biology, signaling pathways, and ... - PubMed
TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered.
The p53 tumor suppressor protein - Genes and Disease - NCBI Bookshelf
The p53 gene like the Rb gene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood.
Targeting p53 pathways: mechanisms, structures and advances in …
Mar 1, 2023 · The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle, apoptosis, and genomic stability, and is...
The multiple mechanisms that regulate p53 activity and cell fate
Mar 1, 2019 · The tumour suppressor p53 has a central role in the response to cellular stress. Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological...
p53 in health and disease | Nature Reviews Molecular Cell Biology
p53 is an important tumour-suppressor protein that is altered in most cancers. p53 activates various responses, including cell-cycle arrest and apoptosis. Each of these appears to contribute...
Tumor suppressor p53: Biology, signaling pathways, and therapeutic ...
Aug 1, 2021 · TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles in development, aging and cell differentiation [2].
The Role of p53 Family in Cancer - PMC - National Center for ...
Feb 6, 2022 · This Special Issue covers a broad topic on the role of the p53 protein family in cancer. The p53 protein is a critical sensor of cellular stress that has evolved in multicellular organisms and is a pivotal tumor suppressor in humans.
p53: A tale of complexity and context - Cell Press
Mar 28, 2024 · The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are still not fully understood, and our discoveries have …
p53: From Fundamental Biology to Clinical Applications in Cancer
Sep 6, 2022 · p53 tumour suppressor gene is the most altered in cancer. Several decades of research have established that it is of pivotal importance in prompting neoplastic phenomena, including cancer initiation and progression. However, it has crucial functions for cellular life.