The Granuloma in Tuberculosis: Dynamics of a Host–Pathogen …
A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the bacteria may disseminate.
Mycobacterial granulomas: keys to a long-lasting host-pathogen ...
Chronic infection with mycobacteria is controlled by the formation of granulomas. The failure of granuloma maintenance results in reactivation of disease. Macrophages are the dominant cell type in granulomas, but CD4+ T cells are the master organizers of …
Understanding the tuberculosis granuloma: the matrix revolutions
Here, we integrate recent evidence from human studies and unbiased approaches to consider how Mtb causes human TB and highlight the recurring theme of extracellular matrix (ECM) turnover. Keywords: tuberculosis, granuloma, bioinformatic analysis, extracellular matrix, metalloprotease.
Modeling the Mycobacterium tuberculosis Granuloma – the Critical ...
Granulomas are the hallmark of Mycobacterium tuberculosis (M.tb) infection and thus sit at the center of tuberculosis (TB) immunopathogenesis. TB can result from either early progression of a primary granuloma during the infection process or ...
In the Thick of It: Formation of the Tuberculous Granuloma and Its ...
Mar 6, 2022 · The defining pathology of tuberculosis is the granuloma, an organized structure derived from host immune cells that surrounds infecting Mycobacterium tuberculosis. As the location of much of the bacteria in the infected host, the granuloma is a central point of interaction between the host and the infecting bacterium.
Generating Three-dimensional Human Granulomas
Nov 11, 2020 · Granulomas are organized multicellular structures that constitute the hallmark of an infection by the human pathogen Mycobacterium tuberculosis (Mtb). A better understanding of the complex host-Mtb interactions within the granuloma’s environment may lead to new therapeutic or preventive tools to improve the control of the tuberculosis pandemic.
Identifying mechanisms driving formation of granuloma …
Sep 9, 2017 · Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a pulmonary pathogen of major global concern. A key feature of Mtb infection in primates is the formation of granulomas, dense cellular structures surrounding infected lung tissue.
The Granuloma in Tuberculosis — Friend or Foe?
Jun 4, 2009 · Contrary to prevailing wisdom, the tubercular granuloma may facilitate, rather than contain, the spread of infection by Mycobacterium tuberculosis.
The formation of the granuloma in tuberculosis infection
Dec 1, 2014 · The development of the granuloma and its subsequent degeneration and necrosis, is the hallmark of infection caused by Mycobacterium tuberculosis. These structures probably evolved as primitive particle responses, but in mammals they are facilitated by the emerging acquired immune response, in which cytokines and chemokines help control their ...
In the Thick of It: Formation of the Tuberculous Granuloma and Its ...
Mar 7, 2022 · The defining pathology of tuberculosis is the granuloma, an organized structure derived from host immune cells that surrounds infecting Mycobacterium tuberculosis . As the location of much of the bacteria in the infected host, the granuloma is a central point of interaction between the host an …