Mitofusin 2: from functions to disease | Cell Death & Disease
Feb 28, 2018 · MFN2, an outer mitochondrial membrane GTPase, is critical for mitochondrial fusion, which in turn affects mitochondrial dynamics, distribution, quality control, and function. MFN2 modulates ER− ...
Marf-mediated mitochondrial fusion is imperative for the ... - PubMed
Feb 15, 2021 · We show here that mitochondrial fusion is critical during early muscle development (in pupa) and that silencing of the outer mitochondrial membrane fusion gene, Marf, in muscles results in smaller mitochondria that are functionally defective.
Marf-mediated mitochondrial fusion is imperative for the …
Feb 15, 2021 · Marf deficiency alters myofibril size and decreases muscle function. Abstract. Dynamic changes in mitochondrial shape and size are vital for mitochondrial health and for tissue development and function. Adult Drosophila indirect flight …
Cardiac Mitochondria: A Surprise about Size - PMC
Manipulation of the genes involved in fission (Drp1) or fusion (MARF and Opa1) can produce similar alterations in mitochondrial size but very different effects on the function of Drosophila hearts. Similarly, knockdown of MARF and Opa1 produce a similar inhibition of mitochondrial fusion and result in a cardiomyopathy, however these functional ...
Mitochondrial fusion but not fission regulates larval growth and ...
Oct 14, 2014 · Mitochondrial fusion and fission affect the distribution and quality control of mitochondria. We show that Marf (Mitochondrial associated regulatory factor), is required for mitochondrial fusion and transport in long axons. Moreover, loss of Marf leads to a severe depletion of mitochondria in neuromuscular junctions (NMJs).
3D Mitochondrial Structure in Aging Human Skeletal Muscle
Nov 13, 2023 · Furthermore, we show that this pathway is evolutionarily conserved with Marf, the MFN2 ortholog in Drosophila, as Marf knockdown alters mitochondrial morphology and leads to the downregulation of genes regulating mitochondrial processes. Our results define age-related structural changes in mitochondria and further suggest that exercise may ...
Mitochondrial fusion regulates lipid homeostasis and stem cell ...
Jun 3, 2019 · Specifically, depletion of either the Drosophila homologue of Mitofusin (known as dMfn or Marf) or Optic Atrophy 1 (Opa1)—GTPases that regulate the fusion of the outer and inner mitochondrial ...
Myofibril and mitochondria morphogenesis are coordinated by a ... - Nature
Apr 7, 2021 · To test our hypothesis, we reduced mitochondrial fusion by knocking down Mitochondrial associated regulatory factor (Marf), a mitofusin required for outer mitochondrial membrane fusion in flight...
Enhancing Mitofusin/Marf ameliorates neuromuscular dysfunction …
Jun 1, 2017 · Importantly, we provide the first in vivo evidence that increasing Marf expression mitigates TDP-43–induced defects in NMJ efficacy and locomotor behavior. Taken together, our data prompt us to propose that the beneficial effects of Marf result, at least in part, from a better integrity of mitochondria due to enhanced fusion events.
Marf-mediated mitochondrial fusion is imperative for the …
Feb 15, 2021 · Marf expression is required during early muscle development. Marf knock down during IFM development affects mitochondrial shape and function. Marf deficiency alters myofibril size and decreases muscle function.