Molecular biology of lung cancer - PMC - PubMed Central (PMC)
The molecular basis of lung cancer is complex and heterogenous. Improvements in our understanding of molecular alterations at multiple levels (genetic, epigenetic, protein expression) and their functional significance have the potential to impact lung cancer diagnosis, prognostication and treatment.
Molecular and Morphological Profiling of Lung Cancer: A …
The pathological diagnosis of lung cancer has largely been based on the morphological features observed microscopically. Recent innovations in molecular and genetic technology enable us to compare conventional histological classifications, protein ...
Frontiers | Lung Cancer: Understanding Its Molecular Pathology …
Aug 27, 2017 · With the emergence of high-throughput sequencing techniques, detailed molecular profiles of lung cancer have been identified. The Cancer Genome Atlas (TCGA) research network identified genomic and other molecular alterations among a number of different types of cancer, including lung cancer.
Molecular Biology of Lung Cancer: Clinical Implications - PMC
Systematic understanding of the molecular basis of lung cancer through comprehensive characterization of aberrations in the cancer genome and their functionality will provide the means to evaluate their use in diagnosis, prognosis and therapy.
Molecular understanding of lung cancers-A review - PMC
Jan 3, 2014 · In order to make an impact on lung cancer, we must understand the molecular abnormalities to target better therapeutics. Lung cancers exhibit multiple genetic lesions including mutations activating the dominant cellular proto-oncogenes as well as those inactivating the tumor suppressor genes.
Molecular pathology of lung cancer: key to personalized …
Jan 27, 2012 · The ability to detect multiple driver mutations in lung adenocarcinoma has revolutionized the medical management of this disease and multiplexed testing for all common driver mutations will ...
The molecular basis of lung cancer: molecular abnormalities and ...
Oct 7, 2003 · The understanding of lung cancer molecular approaches has led to the development of transgenic models using viral antigens, including SV40 large T antigen and polyomavirus (PyV) large and middle T antigens that result in a high frequency of tumors.
Guidelines for molecular testing in non-small cell lung cancer ...
Oct 10, 2023 · In the context of lung cancer, most molecular testing is performed on biopsy specimens since 60% to 70% of patients receive a clinical diagnosis at an advanced stage (IIIB-IV). Regardless of the extent of testing, three fundamental principles guide this process: 1.
Lung Cancer: Understanding Its Molecular Pathology and the …
Aug 28, 2017 · These novel characteristics have enhanced the understanding of the molecular pathology of lung cancer. The identification of driver genetic alterations and potential molecular targets has resulted in molecular-targeted therapies for an increasing number of …
Lung Cancer | New England Journal of Medicine
Sep 25, 2008 · The molecular origins of lung cancer lie in complex interactions between the environment and host genetic susceptibility.