The role of macrophage–fibroblast interaction in lipopolysaccharide ...
Nov 13, 2021 · In this study, we demonstrate that LPS promotes c-Jun N-terminal kinase (JNK) signaling pathway activation and endogenous tumor necrosis factor-α (TNF-α) secretion in pulmonary macrophages.
Lipopolysaccharide-induced murine lung injury results in long …
Jun 17, 2022 · Lipopolysaccharide (LPS)-induced injury is a valuable murine model of ALI but there is a paucity of data on lung regeneration and the role of angiogenic signaling involving vascular...
miRNA-206-3p alleviates LPS-induced acute lung injury via …
May 24, 2024 · Scheme summarizing the protective effects of miRNA-206-3p on LPS-induced acute lung injury by inhibiting TLR4/NF-κB/NLRP3 activation. LPS can induce NF-κB activation through TLR4/MyD88 signaling.
MSCs alleviate LPS-induced acute lung injury by inhibiting the ...
Mar 11, 2024 · Inflammation levels of LPS-stimulated lung organoids–IMs also showed a significant increase, while MSCs suppressed the upregulation of CCL3, CCL4, CXCL1, CXCL2, IL-1β, IL-6, and TNF-α expression (Fig. 5 D).
STING inhibitor ameliorates LPS-induced ALI by preventing …
Dec 14, 2021 · In this study, we explored the molecular mechanisms of STING in regulating lipopolysaccharide (LPS)-induced lung injury. Mice were pretreated with a STING inhibitor C-176 (15, 30 mg/kg, i.p.)...
Lipopolysaccharide-induced murine lung injury results in long …
Jun 17, 2022 · Lipopolysaccharide (LPS)-induced injury is a valuable murine model of ALI but there is a paucity of data on lung regeneration and the role of angiogenic signaling involving vascular endothelial growth factor (VEGF).
LPS-Induced Acute Lung Injury: Analysis of the Development and …
The development of lipopolysaccharide (LPS)-induced ALI, as well as the feasibility of suppressing it by an aptamer targeting the proinflammatory cytokine TNF-α, was studied in a mouse model. The TNF-α level was shown to increase significantly and remain steadily high during the development of ALI.
FGF1 alleviates LPS-induced acute lung injury via suppression of ...
Jun 28, 2022 · FGF1 pretreatment significantly ameliorated the LPS-induced histopathological changes, reduced lung wet/dry ratios, ROS and MDA levels, total BALF protein, inflammatory cell infiltration, proinflammatory cytokine levels, and significantly increased the expression of antioxidant proteins (Nrf-2, HO-1, Catalase, and SOD2).
Bhlhe40 deficiency attenuates LPS-induced acute lung injury …
Feb 24, 2024 · Bhlhe40−/− mice showed alleviative lung pathological injury and inflammatory response upon LPS stimulation. Meanwhile, we found that Bhlhe40 deficiency significantly suppressed GSDMD-mediated pyroptosis in macrophage in vivo and in vitro.
STING mediates LPS-induced acute lung injury by regulating …
May 15, 2024 · In this study, LPS increased the expression of inflammatory factors and the expression of STING in normal human lung epithelial cells BEAS2B in vitro. Furthermore, STING knockdown decreased the level of inflammatory factors, consistent with in vivo experiments.