The Janus-like role of proline metabolism in cancer
Oct 14, 2020 · The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread.
The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic spread....
Structure, biochemistry, and gene expression patterns of the proline …
May 18, 2021 · Proline metabolism refers to the enzyme-catalyzed interconversion of L-proline and L-glutamate (Fig. 1). The biosynthetic and catabolic arms have distinct enzymes but share the common intermediate Δ 1 -pyrroline-5-carboxylate (P5C) and its hydrolysis product, L-glutamate-γ-semialdehyde (GSAL).
Proline-dependent regulation of collagen metabolism - PMC
Nov 18, 2019 · Deregulation of proline metabolism is underlying mechanism of some connective tissue diseases. Proline plays an important role in regulation of gene expression, transcription factors, mTOR cell signaling, cellular redox reactions, synthesis of ornithine, arginine, polyamines, glutamate and collagen.
25.2: Structure and Stereochemistry of the Amino Acids
All naturally occuring proteins from all living organisms consist of L amino acids. The absolute stereochemistry is related to L-glyceraldehyde, as was the case for triacylglycerides and phospholipids. Most naturally occurring chiral amino acids are S, with the exception of cysteine.
Pyrroline-5-carboxylate reductase 1 reprograms proline ... - Nature
Oct 16, 2023 · Targeting proline metabolism or cGMP-PKG signaling pathway provides a potential therapeutic strategy for breast patients undergoing psychological stress. Collectively, our findings unveil that...
Identification of Mammalian Proline Transporter SIT1 …
We found that SIT1 was dramatically up-regulated in the kidneys of 3-day-old mice, accounting for the maturation of proline reabsorption in the mouse. The human slc6a20 gene coding SIT1 is an appropriate target for investigation of hereditary forms of iminoaciduria in man.
Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient ...
Jul 20, 2021 · The reverse conversion of P5C to proline is proline biosynthesis that contains three isoform P5C reductases (PYCRS), which also play important roles in cancer progression.
Protein Science - Wiley Online Library
Jun 22, 2024 · Δ 1-pyrroline-5-carboxylate reductase isoform 1 (PYCR1) is the last enzyme of proline biosynthesis and catalyzes the NAD(P)H-dependent reduction of Δ 1-pyrroline-5-carboxylate to L-proline. High PYCR1 gene expression is observed in many cancers and linked to poor patient outcomes and tumor aggressiveness.
Proline dehydrogenase: a key enzyme in controlling cellular
Jan 1, 2012 · Proline dehydrogenase (ProDH), also called proline oxidase (POX), is a universal enzyme in living organisms. It catalyzes the oxidation of L-proline to delta1-pyrroline-5-carboxylate leading to the release of electrons, which can be transferred to either electron transfer systems or to molecular oxy …