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The algorithm is intended for the treatment of mild to moderately severe major depression (PHQ-9 <20) with the absence of psychotic features. Psychotherapy (cognitive behavior therapy (CBT), interpersonal therapy (IPT) has been shown to have similar
Choice of antidepressant is influenced by adverse effect profile, drug interactions, and cost. Despite their differences, some information applies to all antidepressants. Most antidepressants, unless otherwise noted below, can be given once-daily.
• The ultimate goals of treatment for depression are to achieve remission, return to optimal levels of psychosocial functioning, and to prevent relapse and recurrence of depression. • Adequate documentation should be completed for each algorithm stage and decision point. If
Low risk for drug interactions due to cytochrome P450 interactions. Disadvantages: Doses >40 mg are associated with prolonged QT interval. Avoid concomitant 2C19 inhibitors (i.e., cimetidine, omeprazole); if used with 2C19 inhibitors maximum dose is 20 mg/day. Limited range for dose escalation. ESCITALOPRAM (Lexapro®)
For additional detail, refer to individual Lexidrug monographs included with UpToDate. ¶ Lower doses may be useful for initiating or maintaining patients who are older or medically compromised (eg, kidney or liver disease) or drug-sensitive patients, as well as patients with a …
* Antidepressant use may increase the risk of suicidal thinking and behavior in pediatric and young adult patients with major depressive disorder and other psychiatric disorders. Refer to a drug information resource for more detailed information regarding dosing, adverse reactions, and other safety considerations.
* Antidepressant use may increase the risk of suicidal thinking and behavior in pediatric and young adult patients with major depressive disorder and other psychiatric disorders. Refer to a drug information resource for more detailed information regarding dosing, adverse reactions, and other safety considerations.