COX4I1 - Wikipedia
COX4I1 is a nuclear-encoded isoform of cytochrome c oxidase (COX) subunit 4. Cytochrome c oxidase ( complex IV ) is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane , acting as the terminal ...
Cytochrome c oxidase - Wikipedia
The enzyme cytochrome c oxidase or Complex IV (was EC 1.9.3.1, now reclassified as a translocase EC 7.1.1.9) is a large transmembrane protein complex found in bacteria, archaea, and the mitochondria of eukaryotes. [1] It is the last enzyme in the respiratory electron transport chain of cells located in the membrane.
Cytochrome C Oxidase Subunit 4 (COX4): A Potential Therapeutic …
COX is a bigenomic enzyme with 10 of the 13 subunits being encoded by nuclear DNA and the remaining 3 by mitochondrial DNA. The largest of the nuclear encoded subunits of the COX complex, COX4, is known to function as a regulatory subunit, inhibiting the enzyme activity at high adenosine triphosphate (ATP) concentrations [ 8 ].
1327 - Gene ResultCOX4I1 cytochrome c oxidase subunit 4I1
The ratio of cytochrome c oxidase subunit 4 isoform 4I1 and 4I2 mRNA is changed in permanent atrial fibrillation. Cytochrome c oxidase IV isoform 1 (COX4-1) regulates the proliferation, migration and invasion of trophoblast cells via modulating mitochondrial function.
COX4I1 Gene - GeneCards | COX41 Protein | COX41 Antibody
Dec 24, 2024 · COX4I1 (Cytochrome C Oxidase Subunit 4I1) is a Protein Coding gene. Diseases associated with COX4I1 include Mitochondrial Complex Iv Deficiency, Nuclear Type 16 and Cox Deficiency, Benign Infantile Mitochondrial Myopathy. Among its related pathways are Gene expression (Transcription) and Cellular responses to stimuli.
Cytochrome c Oxidase Subunit IV is Essential for Assembly and ...
COX IV is essential for cytochrome c oxidase assembly. To determine if the down-regulation of COX IV have any effects on the expression of other cytochrome c oxidase complex genes, we examined the protein synthesis of its three biggest subunits, COX I, II and III.
COX4I1 Controls Mitochondrial Electron Transport Chain Complex …
Nov 2, 2023 · Using a high-density CRISPR gene tiling scan (Fig. 2; targeting density ~2.1 aa per sgRNA), we identified two critical COX4I1 peptide regions (P1: K67 - L73 and P2: E136 - K169) required for leukemia cell proliferation and mitochondrial respiration.
Cytochrome C Oxidase Subunit 4 (COX4): A Potential Therapeutic …
Sep 8, 2020 · The nuclear-encoded subunit 4 of cytochrome c oxidase (COX4) plays a role in regulation of oxidative phosphorylation and contributes to cancer progression. We sought to determine the role of COX4 in differentiated (DTC) and medullary (MTC) thyroid cancers.
Upregulation of COX4-2 via HIF-1α in Mitochondrial COX4-1 …
Cytochrome-c-oxidase (COX) subunit 4 (COX4) plays important roles in the function, assembly and regulation of COX (mitochondrial respiratory complex 4), the terminal electron acceptor of the oxidative phosphorylation (OXPHOS) system.
Mutation in the COX4I1 gene is associated with short stature, poor ...
Aug 2, 2017 · We describe a novel autosomal recessive form of mitochondrial disease in a child with short stature, poor weight gain, and mild dysmorphic features with highly suspected Fanconi anemia due to a...