The Cope Elimination: Introduction, Examples and Mechanism
Sep 24, 2018 · The “Cope Elimination” is a reaction where an amine is oxidized to an intermediate called an “N-oxide“, which, when heated, acts as the base in an intramolecular elimination reaction to give a new alkene.
Cope reaction - Wikipedia
The Cope reaction or Cope elimination, developed by Arthur C. Cope, is the elimination reaction of an N-oxide to an alkene and a hydroxylamine. [1] [2] [3] [4] Cope reaction. Typically, the amine oxide is prepared from the corresponding amine with a peroxy acid or comparable oxidant. The actual elimination requires just heat.
Cope Elimination - Organic Chemistry Portal
The Cope Elimination is a syn periplanar elimination in which six electrons move in a five-membered ring according to a concerted, thermally-induced mechanism to yield an alkene and a hydroxylamine: The sterically demanding amine oxide function reacts preferentially with the more easily accessible hydrogens, and often gives good selectivity ...
The Cope Elimination - Chemistry Steps
The elimination proceeds via a five-membered cyclic transition state and it is a one-step, concerted internal elimination during which, the amine oxide serves both as a base and a leaving group. These types of reactions are also referred to as Ei (elimination intramolecular).
Cope Elimination - Chemistry LibreTexts
Jan 23, 2023 · When a tertiary amine oxide bearing one or more beta hydrogens is heated, it is converted to an alkene. The reaction is known as Cope elimination or Cope reaction, not to be confused with Cope …
The Cope Elimination - Chemistry LibreTexts
When a tertiary amine oxide bearing one or more beta hydrogens is heated, it is converted to an alkene. The reaction is known as Cope elimination or Cope reaction, not to be confused with Cope …
Cope Elimination - an overview | ScienceDirect Topics
Cope elimination is a chemical reaction that involves the cleavage of one carbon-hydrogen bond and one carbon-nitrogen bond, leading to the formation of alkenes. It is a significant reaction used in organic synthesis to create various compounds.
Cope elimination - Purechemistry
Mar 20, 2023 · Cope elimination is a chemical reaction that involves the thermal rearrangement of certain organic compounds, leading to the formation of a new molecule. The reaction is named after Arthur C. Cope, who discovered it in 1943.
Cope Elimination - Major Reference Works - Wiley Online Library
The synthesis of olefins from thermal decomposition (i.e., pyrolysis) of N-oxides of tertiary amines is known as the Cope elimination or Cope reaction. The reversal process of this reaction is generally referred to as the reverse Cope elimination or retro -Cope elimination.
Amines to Alkenes: Cope Elimination | Organic Chemistry - JoVE
Cope elimination reaction involves the conversion of tertiary amines to alkene using hydrogen peroxide under thermal conditions, as depicted in figure 1. Figure 1. The Cope elimination …