Brian Finan - Eli Lilly and Company - LinkedIn
Dec 8, 2014 · View Brian Finan’s profile on LinkedIn, a professional community of 1 billion members. Experience: Eli Lilly and Company · Education: Indiana University Bloomington · Location: Indianapolis...
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Brian Patrick Finan - ResearchGate
Brian FINAN | Cited by 5,905 | of Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), München (HZM) | Read 116 publications | Contact Brian FINAN
A rationally designed monomeric peptide triagonist corrects
Dec 8, 2014 · We studied the contribution of the GLP-1 component of the triagonist by testing its metabolic efficacy in high-fat diet–fed (HFD) Glp1r−/− mice. The triagonist decreased body weight by 18.3% ...
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Discovery of a potent GIPR peptide antagonist that is effective in ...
We report a structure–activity relationship of GIPR peptide antagonists based on the human and mouse GIP sequences with fatty acid-based protraction. We assessed these compounds in vitro, in vivo in DIO mice, and ex vivo in islets from human donors.
Finan, Brian – APS 2022
Biography. Brian is currently the Director of Biology at the Novo Nordisk Research Center in Indianapolis, IN USA, which is a Transformational Research Unit, a satellite research center for Novo Nordisk. Brian works at the interface of medicinal chemistry, in …
GLP-1/GIP/glucagon receptor triagonism gets its try in humans
Jan 4, 2022 · Abstract. In this issue, Bossart et al. report the in vivo receptor occupancy, body weight lowering effects in monkeys, and first-in-human results of SAR441255, a balanced GLP-1R/GIPR/GcgR triagonist.
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Author Page for Brian Finan - SSRN
Aug 5, 2020 · 1. The Glucose-Dependent Insulinotropic Polypeptide (GIP) Regulates Body Weight and Food Intake Via CNS-GIPR Signaling. Number of pages: 33 Posted: 05 Aug 2020.
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