What Is Tumor Heterogeneity? - Memorial Sloan Kettering Cancer Center
Jul 2, 2014 · Understanding tumor heterogeneity may be the next big quest in cancer science, as differences between cells within a tumor can have important consequences for how cancers are diagnosed and treated.
Tumour heterogeneity and resistance to cancer therapies
Nov 8, 2017 · In this Review, the authors describe the role of tumour heterogeneity in the development of acquired resistance, potential treatment strategies that take into account the heterogeneity of...
Tumour heterogeneity - Wikipedia
Tumour heterogeneity describes the observation that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. [1]
Tumor heterogeneity: causes and consequences - PMC
Human cancers frequently display substantial intra-tumor heterogeneity in virtually all distinguishable phenotypic features, such as cellular morphology, gene expression (including the expression of cell surface markers and growth factor and hormonal receptors), metabolism, motility, and angiogenic, proliferative, immunogenic, and metastatic ...
Tumor Heterogeneity: A Great Barrier in the Age of Cancer …
We will discuss how tumor heterogeneity causes resistance to various treatments and review the strategies currently being employed to overcome this challenging clinical hurdle. Finally, we will outline areas of research that should be prioritized to gain a better understanding of tumor heterogeneity and develop appropriate solutions.
Tumor heterogeneity: Cancer Cell - Cell Press
Aug 9, 2021 · Tumors are spatially organized heterogeneous ecosystems: at the cellular level, they contain both cancer and stromal cell populations; at the genetic level, they are composed of genetically divergent tumor clones; and at the phenotypic level, cells within different microenvironmental niches acquire distinct phenotypes.
Understanding the Cause and Consequence of Tumor Heterogeneity …
Feb 13, 2020 · Here we discuss the implications of how molecularly targeted therapies in solid malignancies that promote limited cancer cell death may in fact make tumors more heterogeneous, increase aggressive phenotypes, and thus worsen patient outcomes.
Intratumoral heterogeneity in cancer progression and response …
Feb 11, 2021 · Here, we discuss the main sources of intratumoral heterogeneity and its impact on the natural history of the disease, including sensitivity to treatment, as we delineate potential strategies to...
Cancer heterogeneity: implications for targeted therapeutics
Jan 8, 2013 · Intra-tumour heterogeneity is likely to have implications for cancer therapeutics and biomarker discovery, particularly in the era of targeted treatment, and evidence for a relationship...
Tumor heterogeneity 2016 - PMC - National Center for …
Jan 1, 2016 · Heterogeneity is commonplace in all cancer types and at several levels – intrinsic (genetic), epigenetic, positional and at the population level. The different subpopulations with a tumor mass communicate with each other and influence the behavior of other tumor cells both locally and at a distance.