Development of the cerebral cortex - Wikipedia
The development of the cerebral cortex, known as corticogenesis is the process during which the cerebral cortex of the brain is formed as part of the development of the nervous system of mammals including its development in humans.
Developmental mechanisms underlying the evolution of human …
Feb 15, 2023 · Mutations of human-specific genetic modifiers of corticogenesis have started to be linked to neurodevelopmental disorders, providing evidence for their physiological relevance and...
Corticogenesis - an overview | ScienceDirect Topics
Our understanding of corticogenesis has improved exponentially over the past decades. In parallel, advances in molecular genetics have revealed that genetic mutations during embryonic development can result in defects in corticogenesis and generate cortical malformations.
New insights into the development of the human cerebral cortex
Aug 2, 2019 · Mouse cortex is the product of its own unique evolutionary forces that resulted in a small body and lissencephalic brain, a non‐laminated lateral geniculate nucleus, and lateral‐set eyes with minimal binocular vision.
Switching modes in corticogenesis: mechanisms of neuronal …
Aug 10, 2015 · The switch from UL neurons to gliogenesis represents the latest transition in corticogenesis; as this step involves the termination of neurogenesis, the timing of its transition determines the overall number of neurons produced in the neocortex.
An intrinsic mechanism of corticogenesis from embryonic stem cells
Aug 17, 2008 · The discovery of intrinsic corticogenesis sheds new light on the mechanisms of neuronal specification, and opens new avenues for the modelling and treatment of brain diseases.
Cerebral cortex development: an outside-in perspective
Nov 30, 2017 · Radial glial cells (RGCs) derive from neuroepithelial cells and are the founding cortical progenitors. At the onset of corticogenesis, RGCs expand their pool by proliferative divisions.
Heterogeneous fates of simultaneously-born neurons in the …
Apr 11, 2022 · We reveal that early in corticogenesis, isochronic neurons differentiate into heterogeneous laminar, hodological and molecular cell types. Later on, instead, simultaneously-born neurons have...
Post-transcriptional regulation in corticogenesis: how RNA …
Jun 15, 2016 · The cerebral cortex, the brain structure responsible for our higher cognitive functions, is built during embryonic development in a process called corticogenesis. During corticogenesis, neural stem cells generate distinct populations …
From stem cells to comparative corticogenesis: a bridge too far?
Aug 2, 2016 · Are human cortical precursors endowed with specific properties that drive greater neuronal expansion than in other non-human primates? Otani et al. 2016 addressed this issue taking advantage of comparative in vitro corticogenesis models based on human, chimpanzee and macaque pluripotent stem cells. Clonal analysis revealed a heterochrony of ...
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