The CA3 region of the hippocampus: how is it? What is it for ... - PubMed
Feb 5, 2015 · The CA3 region of the hippocampus: how is it? What is it for? How does it do it? Front Cell Neurosci. 2015 Feb 5:9:19. doi: 10.3389/fncel.2015.00019. eCollection 2015. Authors Enrico Cherubini 1 , Richard Miles 2 Affiliations 1 Department of …
Frontiers | The CA3 region of the hippocampus: how is it? what is …
Feb 5, 2015 · An overview of how CA3 neurons process afferent activity from dentate granule cells is provided by Evstratova and Tóth (2014) (Dept. Psychiatry and Neuroscience, Université Laval, Quebec City). They describe how the shape of mossy fiber terminals affects transmission to both CA3 pyramidal cells and interneurons. Transmission exhibits short ...
The CA3 region of the hippocampus: how is it? what is it
The CA3 hippocampal region receives information from the entorhinal cortex either directly from the perforant path or indirectly from the dentate gyrus via the mossy fibers (MFs). According to their specific targets (principal/mossy cells or interneurons), MFs terminate with large boutons or small filopodial extensions, respectively. MF-CA3 synapses are characterized by a low …
Functional Connectivity of Hippocampal CA3 Predicts …
Apr 2, 2020 · Based on anatomical pathways of different hippocampal subfields, computational models of hippocampal function suggested that the CA3 neurons act as an auto-associative network to form and store episodic memories, which are further recoded by CA1 to enable more efficient recall of activity in the neocortical areas (Kesner and Rolls 2015).
Structure and function of the hippocampal CA3 module | PNAS
A recent functional study brought into question much of what had previously been assumed with regard to the CA3 network: Guzman et al. found a very low rate of connectivity among CA3 pyramidal neurons.These sparse connections were often embedded in richly interconnected subnetworks exhibiting an overrepresentation of disynaptic motifs.
Understanding calcium waves and sparks in central neurons
Feb 8, 2012 · Synaptically activated, IP 3-mediated Ca 2+ waves have been observed in pyramidal neurons in the rodent hippocampus (CA1 and CA3 regions), cortex (layer 2/3 (L2/3) and L5) and principal neurons in ...
Neuroanatomy, Hippocampus - StatPearls - NCBI Bookshelf
Jul 20, 2023 · There are four hippocampal subfields CA1, CA2, CA3, and CA4. CA3 and CA2 border the hilus of the dentate gyrus on either side. CA3 is the largest in the hippocampus and receives fibers from the dentate granule cells on their ... specifically glutamatergic neurons in the entorhinal cortex and pyramidal neurons of the CA1 sector of the ...
The CA3 region of the hippocampus: how is it? What is it for? How …
Feb 5, 2015 · An overview of how CA3 neurons process afferent activity from dentate granule cells is provided by Evstratova and Toth (2014) (Dept. Psychiatry and Neuroscience, Universite Laval, Quebec City). They describe how the shape of mossy fiber terminals affects transmission to both CA3 pyramidal cells and interneurons. Transmission exhibits short-term ...
Hippocampal CA3 inhibitory neurons receive extensive …
We find novel noncanonical circuit connections between inhibitory CA3 neurons and vCA1, subiculum complex and other brain regions. Note that the overall connection strength of the vCA1 inputs is similar to that of mossy-fiber inputs. The results support the idea that noncanonical inputs may complement and augment the trisynaptic pathway within ...
CA3 Mossy Fiber Connections: Giant Synapses that Gain Control
Jan 9, 2013 · Of note, CA3 neurons receive DG inputs from the mossy fiber (MF) axons in their proximal dendrites, which form large synapses composed of presynaptic MF boutons and postsynaptic giant spines called thorny excrescences (TEs). CA3 neurons also receive extensive recurrent connections from other CA3 neurons and inputs from the entorhinal cortex in ...