BRAF Mutation and Cancer - Johns Hopkins Medicine
A BRAF mutation is a spontaneous change in the BRAF gene that makes it work incorrectly. A mutation causes the gene to turn on the protein and keep it on, which means certain cells get …
BRAF (gene) - Wikipedia
Mutations in the BRAF gene can cause disease in two ways. First, mutations can be inherited and cause birth defects. Second, mutations can appear later in life and cause cancer, as an …
BRAF Mutation: Cancer Types, Testing, Treatment - Verywell Health
Jun 23, 2024 · BRAF mutations are DNA changes in some cancer cells that can be treated with newer targeted therapies. BRAF mutations are found in roughly half of melanomas. …
BRAF
Apr 16, 2024 · In this review, we cover the current understanding of BRAF mutations and associated clinical characteristics in patients with metastatic NSCLC, approved and emerging …
FDA approves dabrafenib–trametinib for BRAF-positive cancers
Jul 21, 2022 · The Food and Drug Administration (FDA) recently approved the combination of the targeted drugs dabrafenib (Tafinlar) and trametinib (Mekinist) for the treatment of people with …
BRAF gene - MedlinePlus
The BRAF gene mutations, which are found only in the abnormal Langerhans cells, cause the BRAF protein to be continuously active. The overactive protein may contribute to the …
BRAF in Melanoma: Pathogenesis, Diagnosis, Inhibition, and …
Since the initial discovery that a subset of patients with cutaneous melanoma harbor BRAF mutations, substantial research has been focused on determining the pathologic …
Classifying BRAF alterations in cancer: new rational therapeutic ...
Mar 15, 2018 · Approximately 50% of melanoma patients possess a druggable hotspot V600E/K mutation in the BRAF protein kinase. FDA-approved combination therapies of BRAF and MEK …
BRAF: A Two-Faced Janus - PMC - PubMed Central (PMC)
Gain-of-function of V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) is one of the most frequent oncogenic mutations in numerous cancers, including thyroid papillary carcinoma, …
BRAF — a tumour-agnostic drug target with lineage-specific
Jan 26, 2024 · BRAF V600E is by far the most common RAF mutation, accounting for 46.5% of all BRAF alterations in the MSK-IMPACT cohort, with the BRAF V600K/R/D mutants less …