Pathology Outlines - Basal cell carcinoma
Dec 15, 2020 — Definition / general. Basal cell carcinoma (BCC) arises from the interfollicular or follicular epithelium. Most common malignant tumor type in humans. Local aggressive course. Low disease associated death rate; metastases to lung and bone exceptionally rare.
Basal cell carcinoma pathology - DermNet
Histology of basal cell carcinoma The key feature of basal cell carcinoma at low power magnification is of a basaloid epithelial tumour arising from the epidermis (figure 1). The basaloid epithelium typically forms a palisade with a cleft forming from the adjacent tumour stroma (figure 2).
There is no accord of views regarding the type of basosquamous carcinoma. This type is most frequently described as the simultaneous presence of basal cell and squamous cell carcinoma (1,3,5,13,14); some authors report further items, keratotic car-cinoma (3,5,14) and metatypical carcinoma (5,12).
Histologic Mimics of Basal Cell Carcinoma | Archives of Pathology …
Nov 1, 2017 — HISTOPATHOLOGY. Microscopically, BCC is composed of cells with large, elongated nuclei that display variably prominent palisading at the edge of tumor nodules (Figure 1, A). Cytoplasm may be inconspicuous, pale, or lightly eosinophilic. Mitoses and single-cell apoptoses are usually present and may be prominent.
Histopathology of Basal Cell Carcinoma and Its Variants
Dec 18, 2019 — Basal cell carcinomas (BCCs) are epithelial tumors originating from basal layer of the epidermis or follicular infundibulum on sun-exposed skin of adult patients. BCCs in the pediatric population is rare and is almost exclusively seen in association with xeroderma...
Basal cell carcinoma: biology, morphology and clinical ... - Nature
Jan 17, 2006 — We distinguish these neoplasms from keratotic BCC, which is most often a nodular BCC with central squamous differentiation, and from the mixed basal cell–squamous cell carcinomas that represent...
Cornification (keratinization) in Basal cell carcinoma: a ... - PubMed
To elucidate the histopathological and immunohistochemical properties of cornification in BCC and to clarify the concept of keratotic BCC, by careful examination of 600 BCC specimens, we selected 16 cases of BCC that showed cornification. …
Basaloid skin tumours: Basal cell carcinoma - Current Diagnostic Pathology
Basaloid tumours are defined as those that appear more blue than pink on haematoxylin and eosin (H&E) staining. Basophilia is a consequence of a high nuclear:cytoplasmic ratio and relatively condensed nuclear chromatin. Basal cell carcinoma (BCC) …
Keratinocyte carcinomas (KCs) are by far the most common malignancies worldwide and exceed the prevalence of all other cancers combined. Traditionally, approximately 80% of KC cases have been attributed to basal cell carcinoma (BCC) and 20% to squamous cell carcinoma (SCC).
Basal cell carcinoma - Journal of the American Academy of …
This 2-part continuing medical education series provides a comprehensive and contemporary review of basal cell carcinoma. The second article in this series will present both the current standard of care and newly developed approaches to …