Homepage | Journal of Neurology, Neurosurgery and Psychiatry …
5 days ago · Journal of Neurology, Neurosurgery and Psychiatry is a Plan S compliant Transformative Journal. Journal of Neurology, Neurosurgery and Psychiatry (JNNP)'s ambition is to publish the most ground-breaking and cutting-edge research from around the world. Encompassing the entire genre of neurological sciences, our focus is on the common disorders (stroke, multiple sclerosis, Parkinson's disease ...
Cyclophosphamide for myasthenia gravis: a comeback? | Journal of ...
Myasthenia gravis (MG) treatment’s landscape has dramatically changed with the approval of novel therapeutics that can provide rapid improvement, including in patients typically considered refractory. These treatments are a welcome addition in MG, since a proportion of patients traditionally considered ‘responders’ to standard treatments, …
Routine CSF parameters as predictors of disease course in multiple ...
Background It remains unclear whether routine cerebrospinal fluid (CSF) parameters can serve as predictors of multiple sclerosis (MS) disease course. Methods This large-scale cohort study included persons with MS with CSF data documented in the MSBase registry. CSF parameters to predict time to reach confirmed Expanded Disability Status Scale (EDSS) scores 4, 6 and 7 and annualised relapse ...
Jun 14, 2018 · The aim was to capture interdisciplinary expertise from a large group of clinicians, reflecting practice from across the UK and further, to inform subsequent development of a national consensus guidance for optimal management of idiopathic intracranial hypertension (iiH). Methods Between September 2015 and October 2017, a specialist interest ...
CAUSES OF VIRAL ENCEPHALITIS - Journal of Neurology, …
Encephalitis refers to an acute, usually diffuse, inflammatory process affecting the brain. While meningitis is primarily an infection of the meninges, a combined meningoencephalitis may also occur. An infection by a virus is the most common and important cause of encephalitis, although other organisms may sometimes cause an encephalitis. An encephalitic illness caused by alteration of normal ...
Genetics of inherited peripheral neuropathies and the next frontier ...
Inherited peripheral neuropathies (IPNs) encompass a clinically and genetically heterogeneous group of disorders causing length-dependent degeneration of peripheral autonomic, motor and/or sensory nerves. Despite gold-standard diagnostic testing for pathogenic variants in over 100 known associated genes, many patients with IPN remain genetically unsolved. Providing patients with a diagnosis is ...
Lacunar stroke is defined as a subcortical infarct measuring less than 20 mm in diameter, caused by occlusion of a perforator of an intracranial artery.1 In this narrative review, we aim to provide an over-view of potential lacunar stroke mechanisms and diagnostic approaches, and discuss therapeutic implications targeting the underlying mechanism.
Highlighting the past and future of inherited peripheral neuropathies
Inherited peripheral neuropathies (IPN) are among the most common inherited conditions in Neurology and are still largely not treatable. It is thus of great medical and public interest to understand IPN aetiologies more fully and enable the rational development of therapeutics. Similar to other inherited neurological disorders, the diagnostic gap is still substantial for IPN with an estimated ...
Migraine and risk of stroke | Journal of Neurology, Neurosurgery ...
Migraine and stroke are two common and heterogeneous neurovascular disorders responsible for a significant burden for those affected and a great economic cost for the society. There is growing evidence that migraine increases the overall risk of cerebrovascular diseases. In this review, based on available literature through a PubMed search, we found that ischaemic stroke in …
Recurrent Guillain–Barré syndrome - Journal of Neurology ...
Guillain–Barré syndrome (GBS) is an acute polyradiculoneuropathy leading to flaccid paresis. Its annual incidence rate is 0.75 to 2 per 100 000.1 2 GBS is a heterogeneous disease in which approximately two-thirds of patients report a preceding incident, usually an infection, such as diarrhoea or an upper-respiratory-tract infection. Although GBS is …