Programmed cell death 4 mechanism of action: The model to be …
Programmed cell death 4 (Pdcd4) is a tumor suppressor inhibiting cap-dependent translation from mRNAs with highly structured 5′-regions. 1, 2 Pdcd4-mediated translational suppression relies on its interaction with eIF4A helicase (namely, eIF4A1 and eIF4A2) 2 resulting in inhibition of eukaryotic translation initiation factor 4A (eIF4A) helicase activity and precluding from eIF4A:eIF4G ...
Programmed cell death factor 4 (PDCD4), a novel therapy target …
Nov 1, 2020 · Programmed cell death factor 4 (PDCD4) is originally described as a tumor suppressor gene that exerts antineoplastic effects by promoting apoptosis and inhibiting tumor cell proliferation, invasion, and metastasis.
Role of programmed cell death 4 in diseases: a double-edged …
Sep 18, 2017 · Programmed cell death protein 4 down-regulates Y-box binding protein-1 expression via a direct interaction with Twist1to suppress cancer cell growth. Cancer Res 2009; 69 : 3148–3156.
Role of programmed cell death 4 in diseases: a double-edged …
Sep 18, 2017 · The molecule of programmed cell death 4 (PDCD4) is named based on its upregulation during apoptosis. It is now known that PDCD4 is highly conserved during evolution and widely expressed in the immune cells and non-immune cells of humans and other animals.
The clinical association of programmed cell death protein 4 …
Programmed cell death protein 4 (PDCD4) is a novel tumor suppressor protein involved in programmed cell death. Its association with cancer progression has been observed in multiple tumor models, but evidence supporting its association with solid tumors in …
Programmed cell death protein 4 (pdcd4): A novel target for ...
Nov 1, 2003 · Pdcd4 is a novel gene first identified as a differentially expressed protein during apoptosis. In the meantime not only the impact of Pdcd4 in programmed cell death but also an implication in transformation suppression by inhibition of protein translation is discussed.
Programmed cell death protein 4 (pdcd4): a novel target for
Pdcd4 is a novel gene first identified as a differentially expressed protein during apoptosis. In the meantime not only the impact of Pdcd4 in programmed cell death but also an implication in transformation suppression by inhibition of protein translation is discussed.
Programmed cell death protein 4 (pdcd4): A novel target for ...
Nov 1, 2003 · Pdcd4 is a novel gene first identified as a differentially expressed protein during apoptosis. In the meantime not only the impact of Pdcd4 in programmed cell death but also an implication in transformation suppression by inhibition of protein translation is discussed.
Programmed cell death 4 modulates lysosomal function by
Oct 25, 2020 · Here, we found that programmed cell death 4 (PDCD4), a tumor suppressor, decreased levels of nuclear TFEB to inhibit lysosome biogenesis and function. Mechanistically, PDCD4 reduces global...
PDCD4 Gene - GeneCards | PDCD4 Protein | PDCD4 Antibody
Oct 2, 2024 · PDCD4 (Programmed Cell Death 4) is a Protein Coding gene. Diseases associated with PDCD4 include Colorectal Cancer and Lung Cancer . Among its related pathways are Interleukin-12 family signaling and Cytokine Signaling in Immune system .