History has shown us that divisional matchups could end up closer than expected, but you couldn't tell that from many of the Week 16 NFL odds. Bills vs. Patriots has Buffalo favored by 14 points in the largest of the Week 16 NFL lines and one of the biggest NFL spreads of the season.

The Cincinnati Bengals are clinging to faint playoff hopes entering the Week 16 Battle of Ohio against the Browns, who are making a change at quarterback from Jameis Winston to Dorian Thompson-Robinson.

Our first lookahead line best bet for Week 17 will be the New Orleans Saints on the moneyline. I'm still getting the hang of gaining positive EV on an underdog. We've done it a couple of times. However, primarily, we've hunted betting favorites, and they've usually been very public plays.

There are only three weeks left in the NFL regular season. Now is when the contenders make names for themselves and the pretenders fall apart. Despite the short window before the postseason, only half of the playoff spots have been clinched – four in the AFC,

SportsLine's top NFL experts reveal their NFL picks, NFL predictions, NFL betting tips, and NFL best bets for Week 16

With the NFL regular season coming to a close soon, the playoff picture is quickly forming. This is the time of year where everything is on the line, and for some teams it's make or break. So who wins in NFL's week 16?