Mutations in NPC1 cause Niemann-Pick Type C. Mice lacking NPC1 only in microglia have rampant neuroinflammation and impaired ...

UC San Diego Health is one of a few health care systems on the West Coast to offer a new gene therapy for hemophilia B, a ...

Fighting off infections when one has a chronic disease is a common problem, and during the COVID-19 pandemic that scenario ...

During islet development, beta-cell death, rather than proliferation alone, regulates beta-cell mass and shapes the immune ...

Calcipotriol-plus–5-FU therapy activates immune pathways, offering long-lasting protection against squamous cell carcinoma by ...

Tevimbra is under clinical development by BeiGene and currently in Phase II for Marginal Zone B-cell Lymphoma.

relapsed or refractory mantle cell lymphoma, primary mediastinal [thymic] large B-cell lymphoma (PMBCL) and other B-cell malignancies, coronavirus disease 2019 (COVID-19), primary and secondary ...

Regulatory T (T Reg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity and limiting chronic inflammatory diseases. However, they also limit beneficial responses by ...

Since Tregs, particularly those committed in the thymus (tTregs), play a non-redundant role in the ... CVID patients are characterized by decreased class-switched memory B cells (4) but autoimmune ...

CD4 T helper cells are a type of white blood cell called a lymphocyte that serves an important role in your immune system. These cells help defend the body against infection by directing other "killer ...

Sham thymectomy involved a complete surgical procedure without thymic lobe removal. Thymectomized mice were allowed a six-week recovery period. For single-cell suspension preparation, tumors were ...