By putting a carbon atom in place of a core oxygen, chemists constructed an opioid that blocks pain with less respiratory ...

A controlled/"living" click polymerization method developed by researchers at the Institute of Science Tokyo and Nagoya ...

Controlling regioselectivity remains one of the major challenges in hydrocyanation. When an unsymmetrical alkyne undergoes this reaction, it typically yields a mixture of regioisomers. This ...

Copper nanoparticles were synthesized using chemical reduction method by reduction of copper sulphate as a metal precursor and sodium borohydride as reducing agent. The particles are characterized and ...

The advent of modern antibiotics contributed enormously to the dramatic extension of human lifespan since their discovery by virtue of their lethal and selective action against pathogenic microbes ...

The secondary metabolites from Hericium erinaceus are well-known to have neurotrophic and neuroprotective effects. Isohericerinol A (1), isolated by our colleagues from its fruiting parts has a strong ...

We present the first total synthesis of eight ent-pimaranes via a short and enantioselective route (11–16 steps). Key features of the divergent synthesis are a Sharpless asymmetric dihydroxylation, a ...

Synthesis of case reports/series A single patient case report does not allow the estimation of an effect size and would only provide descriptive or narrative results. Case series of more than one ...

Glyburide increases insulin secretion, and it decreases insulin resistance by reducing glucose toxicity. Its onset of action is approximately 4 h, and its duration of action is approximately 10 h.

Data Synthesis: Studies of glyburide and glipizide have found little or no transfer of these drugs across the placenta, whereas metformin and rosiglitazone cross readily.