Controlling regioselectivity remains one of the major challenges in hydrocyanation. When an unsymmetrical alkyne undergoes this reaction, it typically yields a mixture of regioisomers. This ...

Inside our cells, ribosomes—the tireless "protein factories" of life—have just shown off a new skill they haven't used in ...

Data Synthesis: Studies of glyburide and glipizide have found little or no transfer of these drugs across the placenta, whereas metformin and rosiglitazone cross readily.

Our Idea Researchers developed a synthesis technique that enables the formation of 2D copper boride by depositing atomic boron on copper surfaces at elevated temperatures.

Glyburide was found to be less effective in preventing GDM complications in comparison with insulin and metformin, probably because it readily crosses the placenta, and should not be used as the first ...

2. Glyburide probably results in an increased risk of hypoglycaemia (low blood sugar). 3. More and larger studies are needed to better understand the effects of sulfonylurea on people after a severe ...

In a study appearing in Nature Chemistry, researchers at the University of California, Davis Institute for Psychedelics and Neurotherapeutics (IPN) report the successful total synthesis of ibogaine, ...

Glyburide was added to metformin, and if needed to achieve glucose targets, insulin was then substituted for glyburide. Overall, 79% of the participants randomly assigned to oral agents maintained ...

Glyburide was the most commonly prescribed therapy for gestational diabetes in 2011, largely due to a trial that found it achieved blood glucose concentrations similar to insulin, Powe pointed out.