Prx1 is a paired-box homeodomain transcription factor, with an established role in limb bone growth. Dr. Behringer and colleagues identified a conserved Prx1 enhancer domain, which regulates ...

Repair of the peroxiredoxin Prx1 consequently emerges as a key process in aging. "Impaired Prx1 function leads to various types of genetic defects and cancer. Conversely, ...

In the Jan. 15 issue of G&D, a research team led by Dr. Richard Behringer at MD Anderson Cancer Center reports that they have successfully switched the mouse Prx1 gene regulatory element with the ...

Restricting calorie intake has been shown to delay the aging process and the enzyme Prx1 has been identified as playing a major role. Noel McKeegan/New Atlas. View 2 Images 1 / 2.

Nature Reviews Genetics - Preparing for take off. So what does Prx1 do? It is not entirely clear, but it could be involved in chondrocyte proliferation and eventual differentiation.

The researchers focused on a gene, Prx1, that plays a part in the elongation of limb bones in mammals. The gene’s expression is regulated by another sequence of DNA, called a Prx1 enhancer.

Silencing Prx1 and/or Prx5 by RNAi sensitizes human Eca-109 and TE-1 cells to IR, and the intracellular ROS accumulation may contribute to the radiosensitizing effect of the RNAi.

In the limb bones of the mutant mice, Prx1 was 70 percent more active than in unaltered mice. More striking, the mutant embryo limbs grew slightly longer than those of normal mice, when measured a ...

Kaori Ihida-Stansbury 1,2, Juliana Ames 1, Mithil Chokshi 1,2, Norman Aiad 1, Sonali Sanyal 1, Kimihito C. Kawabata 3, Ilya Levental 1, Harini G. Sundararaghavan 4, Jason A. Burdick 4, Paul Janmey 1, ...

But even those differences are not as major as you might imagine. Mice and bats both have a gene called Prx1, which regulates limb development. But the gene is more active in the budding wings of ...