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Researchers reveal key differences in STING inhibition between humans and mice
Researchers have long focused on the STING (Stimulator of Interferon Genes) pathway as a way to harness the immune system's ...
Mirage News1d
Mitochondrial Link in Skin Cancer: Drug Hope Emerges
A new study led by researchers at Lund University in Sweden, reveals that melanoma, the deadliest form of skin cancer, can in some cases be driven by ...
C&EN5d
Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer’s Disease ...
Concomitant inhibition of butyrylcholinesterase (BChE) and histone deacetylase 6 (HDAC6) is supposed to be effective in the treatment of Alzheimer’s disease (AD). Inspired by our previous efforts in ...
C&EN6d
Synthesis of a Transition State Analogue Inhibitor of Purine Nucleoside Phosphorylase via the Mannich Reaction | Organic Letters - ACS Publications
The expeditious convergent synthesis of the potent human purine nucleoside phosphorylase inhibitor DADMe-Immucillin-G (3) was achieved via the Mannich reaction. The Mannich chemistry of a series of ...