Researchers have long focused on the STING (Stimulator of Interferon Genes) pathway as a way to harness the immune system's ...

A new study led by researchers at Lund University in Sweden, reveals that melanoma, the deadliest form of skin cancer, can in some cases be driven by ...

Researchers have discovered that the most aggressive melanomas, the deadliest form of skin cancer, overactivate two key ...

Summary The field of protein production is seeing widespread adoption of cell-free protein synthesis (CFPS), revolutionising the industry with its high-throughput and cost-effective capabilities. This ...

A Cornell University-led collaboration has uncovered the equipment that enables bacteria to survive exposure to antibiotics: a shuttling mechanism that helps a complex of proteins pump out a wide ...

The bacterial DNA replication machinery presents new targets for the development of antibiotics acting via novel mechanisms. One such target is the protein–protein interaction between the DNA sliding ...

By using selective inhibitors to target each isoform, they were able to identify and isolate the isoforms that are active in the spinal cord from Hsp90-alpha, the one that is active in the brain.

Elkrief, A, el Raichani, L, Richard, C, Messaoudene, M, Belkaid, W, Malo, J, et al. Antibiotics are associated with decreased progression-free survival of advanced melanoma patients treated with ...

The present synthesis method will hopefully lead to the creation of various compounds for pharmaceuticals in the future, including new antibiotic candidates for multidrug-resistant bacteria." ...

The past decade has been testament to the diffusion of immune checkpoint inhibitors (ICIs) as part of the therapeutic armamentarium of nearly every oncologic indication. The unquestionable advances in ...