A research team have recently published their article, "Rationally designed pooled CRISPRi-seq uncovers an inhibitor of ...

"Magnesium is an essential mineral that's crucial in multiple bodily functions, including regulating blood sugar and blood ...

In addition to the urgent need for new antibiotics, alternative strategies are required to tackle the problem of antibiotic resistance. Michaela Wenzel, Associate Professor at Chalmers University of ...

Researchers from the University of Washington are developing new antibiotics targeting bacterial methionyl-tRNA synthetase (MetRS). This enzyme is responsible for charging tRNA(met) with methionine ...

A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

These biomolecules, which came to be known as naphthocyclinones, are representative of a family of antibiotics with ... concise strategy toward heterodimer synthesis via the logical design of ...

However, in PKCλ/ι-deficient cells treated with androgen receptor inhibitors ... They found that inhibiting either protein synthesis or the TGF-β pathway effectively reversed resistance ...

This important study by Bi and colleagues employed a clever genetics screen to uncover the role of the GidB rRNA methylase in translation fidelity, under certain conditions, in Mycobacterium smegmatis ...

We also prioritized compounds that work differently from existing antibiotics to minimize cross-resistance. Finally, we tested how effectively our inhibitors could overcome antibiotic resistance in E.