This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The ...

Despite technologic advances in drug resistance testing, clarification of assay interpretation, assay standardization, and the results from validation studies are needed. This review discusses ...

Brain disorders like Parkinson's (PD) or Alzheimer's Disease (AD) start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages ...

Brain disorders like Parkinson's or Alzheimer's Disease start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages could slow or ...

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2R3, Canada Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada Department ...

To achieve this, we combined a high-yield size-exclusion chromatography protocol with an optimized protease protection assay and Single Molecule Array (Simoa) digital enzyme-linked immunoassays ...

we used SEC isolation methods that we previously developed to isolate most EVs from plasma together with an optimized 'proteinase protection assay' where we use an enzyme to gently but efficiently ...

The longest-used assay depends on ingredients from ... This binding changes factor C’s shape and activates its protease abilities. Now active, the enzyme cleaves itself and then other proteins ...

Center for 4D cellular dynamics, Department of Chemistry, University of Copenhagen, Copenhagen 2100 Denmark Novo Nordisk Challenge Center for Optimised Oligo Escape and Control of Disease, Copenhagen ...