The causes of hereditary spherocytosis are mutations in genes that encode red blood cell (RBC) membrane and cytoskeletal ... activate the transcription of the globin gene and hemoglobin accumulation.

Impaired lysosomal function (breaking down waste) leads to accumulation of excess lipids in liver cells, worsening NAFLD and contributing to its progression. By analyzing a clinical gene-profiling ...

Familial Chilomicronemia Syndrome (FCS) is a genetic disease that causes persistent accumulation of triglycerides ... researcher of the Lipids and Arteriosclerosis Laboratory of the Health and ...

Cancer cells can become resistant to chemotherapy over time, reducing its effectiveness. Researchers at the University of Geneva (UNIGE) discovered specific lipid changes in chemotherapy-resistant ...

Even though the brain has been well-thought as an immunoprivileged organ, uncontrolled inflammation and abortive resolution of inflammation are common in ...

J Midwifery Womens Health. 2008;53(3):227-235. Once they have colonized the uterine cavity, bacteria can not only infect the fetus but also can release endotoxins that, in sufficient quantities ...

Primary liver cells from both genotypes of mice were isolated for in vitro experiments. Results TREM-2 was expressed on non-parenchymal hepatic cells and ... challenge was associated with elevated ...

Inhibiting this signal induces tumor regressions by triggering progenitor-to-hepatocyte differentiation, the same cell fate-switch that Notch controls during development. Transcriptomic analysis ...

These findings were validated by histopathological characterization of each tumor, including cell density and proliferation, peritumoral invasion and distant migration, and immune cell infiltration.