Kronos Bio (KRON) announced preclinical data from its p300 KAT inhibitor program for human papillomavirus-driven tumors at the EORTC-NCI-AACR ...

In the presentation titled, "Oncogenic human papillomavirus hijacks p300 to drive viral transcription, creating a therapeutic vulnerability that can be exploited with selective p300/CBP catalytic ...

However, several limitations for this class of drugs remain. For anti-telomerase drugs to engage p53-dependent apoptotic and/or senescence pathways to suppress tumorigenesis, an intact p53 pathway ...

At this time, membranes were incubated with the following monoclonal antibodies: 5 µg/mL anti-p53 (clone Pab 240), 5 µg/mL antiphospho-p53 (serine 392) [both from Calbiochem-Novabiochem ...

Data show that p300 KAT inhibitor KB-9558 was highly selective against human papillomavirus (HPV) oncoproteins E6 and E7, and ...

In case you didn’t know, two motor shows are happening simultaneously this week. But before anyone could pull the covers off ...

It is with great sadness and heavy heart that we announce the recent passing of Dr. Mikhail (Misha) V. Blagosklonny, our ...

Gemtuzumab ozogamicin, a potent anti-CD33 calicheamicin antibody-drug conjugate (ADC ... SWTX-143 treatment was well tolerated in mice but induced tumor regression in xenograft and Lats1/2;p53 mutant ...

A wave of high-profile hate crimes at the beginning of the COVID-19 pandemic drew national ire over anti-Asian attacks. But the new survey, shared exclusively with USA TODAY, shows that the Asian ...

Wednesday, we learned why. Anti-DEI backlash has sent the company spinning. The Paris-based video game publisher pushed the release of its biggest game of the year from November 12 to February 14 ...

This intimidation technique, Katyal suggested, is also part of the anti-DEI movement’s strategy to file class action lawsuits against young startups. “Some of these Steven Miller-types are ...