This neurogenic inflammation represents a paradigm shift in how scientists understand pain, particularly in perplexing chronic conditions that have historically eluded effective treatment.

Chronic pain affects millions of people in the US. Targeting an oft-overlooked brain receptor could one day offer relief.

Dysesthesia is what's called neuropathic or neurogenic pain. That means it comes from your nervous system. Although you feel the pain in your feet or skin, that isn't where the problem is.

Explore the latest guidelines for treating neuropathic pain, based on a comprehensive study by the International Association for the Study of Pain’s NeuPSIG. This research evaluates both drug ...

Background Best current estimates of neuropathic pain (NeuP) prevalence come from studies using various screening detecting pain with probable neuropathic features; the proportion experiencing ...

Neuropathic pain doesn’t just affect the body – it also alters the brain. Chronic pain of this nature often leads to depression, anxiety, social isolation and a deep sense of helplessness.

Sidebar Executive Summary. Mechanisms Underlying Neuropathic Pain. Electrophysiological recordings demonstrate that the regenerating C-fibers of damaged axons develop ongoing spontaneous activity ...

Neuropathic pain has no immediate cause – research on a brain receptor may help stop this hard-to-treat condition. By Pooja Shree Chettiar, Texas A&M University June 23, 2025 ...