This study investigates the role of macrophage lipid metabolism in the intracellular growth of Mycobacterium tuberculosis. By using a CRISPR-Cas9 gene-editing approach, the authors knocked out key ...

Aged macrophages exhibit impaired lipid droplet clearance and reduced autophagy and efferocytosis, key processes essential for resolving atherosclerotic plaques. Quantitative proteomics reveal ...

Figure 1 - figure supplement 2 Lipid droplet formation and fatty acid oxidation in PLIN2-/-and CPT2-/-macrophages. (A) Phenotypic characterization of lipid droplet biogenesis in PLIN2-/-macrophages.

Lipid droplet; IL-1β, interleukin-1β; Lyso, lysosome; TNF-α, tumor necrosis factor alpha; TREM2, triggering receptor expressed on myeloid cells-2. 2.3 Activating TREM2 signaling promotes cholesterol ...

When a droplet of water falls on a hot pan, it dances across the surface, skimming on a thin layer of steam like a tiny hovercraft; this is known as the Leidenfrost effect.

A new review published in Genes & Diseases highlights macrophage-targeted therapy as a promising frontier in cardiac regeneration and myocardial repair.

One type of immune cell residing in nerves, a pro-inflammatory macrophage, began producing chemokines. These signaling molecules recruited a second population of circulating macrophages ...

Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. Nature Materials , 2025; DOI: 10.1038/s41563-024-02114-5 Cite This Page : ...

"Driven by a keen interest in lipid droplet functions in aging and disease, we initiated this fruitful collaboration to harness cutting-edge SRS technology for studying lipid metabolism in ...