Human cell transformation systems revealed that RAL-GEF signaling is particularly required for oncogenic RAS function in human cancer. Murine Kras-driven lung cancer models have confirmed the key ...

A lethal, mutant version of the KRAS signaling enzyme was often called undruggable—until researchers found a molecule that has the potential to lock onto this cancer-causing protein.

The KRAS gene is responsible for producing a protein also called KRAS that’s involved in regulating the entrance of signaling molecules into the nucleus of a cell. Many of the nuclear signaling ...

SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS, and recent preclinical studies have demonstrated that combining KRAS and EGFR inhibitors with SOS1 inhibitors can overcome ...

Androgen receptor (AR) signaling is the primary driver of prostate cancer (PCa) disease progression, resulting in about 27,500 deaths per year in the US. First line treatment of PCa is androgen ...

2014;15(11):1507-1518. Taken together, these studies have firmly established RAF, PI3K and RAL signaling as key downstream effectors of KRAS that promote lung tumorigenesis. While other direct RAS ...