Immune checkpoint pathways regulate T cell function and play pivotal roles in the treatment of both cancer and autoimmune ...

During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...

A recent research finding adds to evidence that brain inflammation is a major driver of neurodegenerative disorders such as ...

Given these findings support the idea that dysfunctions in synapse elimination may extend beyond microglia to peripheral immune cells such as macrophages, Dr. Manabu Makinodan, who is the ...

Repertoire Immune Medicines Inc. has entered into a collaboration and license agreement with Genentech Inc., a member of the Roche Group, to discover and develop innovative T cell-targeted immune ...

We identified distinct methylation patterns in immune synapse genes, differentiating tumors from adjacent normal tissues. Co-stimulatory genes such as CD40 were hypermethylated in tumors, correlating ...

AbstractBackground:. Plasmacytoid dendritic cells (pDCs), a unique type of innate immune cells, are known to play an important role in fighting viral infections, especially due to their capacity to ...

They found that CD28.ζ-CAR molecules shuttle through the immune synapse quickly, working within minutes to kill cancer cells. This enabled fast CAR T cell recovery and a mastery of “serial killing” of ...

This letter proposes a single event upset (SEU)-hardened task-scheduling logic-in-memory xnor/xor neuron and synapse circuit. Using a C-element and a magnetic tunnel junction enhances immunity against ...

Abstract: This letter proposes a single event upset (SEU)-hardened task-scheduling logic-in-memory xnor/xor neuron and synapse circuit. Using a C-element and a magnetic tunnel junction enhances ...