The synapse Davis refers to is the immunological synapse, where T cells receive their marching orders; understanding it is vital to appreciating how an immune response is set in motion. "We like to ...

Immunological synapse (IS) formation is a key part of developing and sustaining immune responses against cancer and is necessary for T cells and NK cells to eliminate tumor cells. This webinar will ...

During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...

Switching immune cells on is a critical step in combating infection. In the case of T cells, which are key players in immunity, this happens when dormant T cells circulating in the blood encounter ...

The study, published in the November 18, 2005, issue of Science, reveals how T cells analyze and react to the signals of infection at the immunological synapse.

The immunological synapse is the crossroads of the adaptive immune system, through which helper T cells instruct B cells to induce antibody production or killer T cells latch onto infected and ...

The immunological synapse is a thing of beauty to behold under a microscope but the kiss of death for a cancer cell. "Synapse" is the word used to describe prolonged contact between a T cell and ...

Actin reorganization at the immunological synapse is required for the amplification and generation of a functional immune response. Using small interfering RNA, we show here that dynamin 2 (Dyn2 ...

Given these findings support the idea that dysfunctions in synapse elimination may extend beyond microglia to peripheral immune cells such as macrophages, Dr. Manabu Makinodan, who is the ...

The immunological synapse can be described as a superstructure initiated at the contact surface between the T cell and the antigen presenting cell (APC) that optimizes activation by congregating ...

In mice that express LAG3 (left image), accumulation of LAG3 at the immunological synapse in T cells lowers the pH, making conditions more acidic (green and blue) compared with less acidic (red ...