Isolation of Potential Liver Stem/Progenitor Cells A unique, specific marker for LSCs in the adult liver has not yet been assigned, and because these cells are not under constant renewal, unlike ...

“ We achieved a prominent growth of hiPSC-derived liver organoids driven by hepatoblast expansion through the careful recapitulation of molecular events governed by extrinsic factors observed in ...

Downstream of Notch and these other signaling pathways, transcription factor networks control cell fate, proliferation and differentiation; in particular, HNF4A functions centrally in hepatoblast ...

Research on hepatic stem cells has entered a new era of controversy, excitement, and great expectations. Although adult liver stem cells have not yet been isolated, an enormous repopulating ...

First, we show that intrahepatic ALGS-like pericellular fibrosis is recapitulated in Jag1Ndr/Ndr mice. Combining single-cell transcriptomics and flow cytometry, we identify dysregulation of maturing ...

The expression level of the prominin 1-encoding gene (CD133, a liver oval cell/hepatoblast marker) was higher in the hLOs from the MPS than in those from the conventional droplet culture.

The hepatoblast‐like terminal state (that expanded under OA treatment, Fig 4B) showed enrichment for hepatocyte precursor defining transcripts AFP, APOA1, APOC1, HNF4A, and CEBPA, providing further ...

Using this device, on-chip differentiation of Human HepaRG-hepatoblast (HepaRG-HB) to HepaRG-Hepatocytes (HepaRG-HC) has been studied in terms of self-organization capabilities, bile canaliculi ...

“Studies of hepatoblastoma that focus exclusively on tumor cells demonstrate sparse somatic mutations and a common cell of origin, the hepatoblast, across patients.

Forward programming of human pluripotent stem cells with a combination of four transcription factors allows the production of functional hepatocytes.

A hepatoblast is the precursor in the fetus of a hepatocyte, or fully formed liver cell, and it is very similar in various ways to intestinal epithelial cells—the protective cells that line the ...

Feature selection is the process of selecting a subset of landmark features for model construction when there are many features and a comparatively few samples. The far-reaching development ...