NNRTIs bind to a hydrophobic pocket near the catalytic site of HIV-1 RT and inactivate enzymatic activity. NNRTI-resistance mutations & their mechanism of drug resistance The most prevalent NNRTI ...

BEEHIVE follows individuals enrolled in eight cohorts across Europe and Uganda to understand better the molecular basis of HIV strains and which mutations in HIV's genetic sequence are associated ...

Avian influenza viruses typically require several mutations to adapt and spread among humans, but what happens when just one ...

Javier Martínez-Picado is one of the leading researchers in the fight against AIDS and coordinates the international consortium IciStem from Barcelona. Behind some of the most important recent ...

A new study by biologists from the Scripps Research Institute shows that a bird flu virus is just a single mutation away from ...

This work is published in Science in the paper, “A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors.” Influenza viruses attach to cells using ...

The potential mutation would allow the avian influenza virus sweeping through dairy herds to attach to a receptor protein on ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

A man has been effectively cured of HIV and leukaemia in a development that offers huge promise to disease researchers. Paul Edmonds, 68, was diagnosed with AIDS in 1988. In 2018, he was also ...

Recent study reveals H5N1 mutations enhancing human receptor binding, highlighting pandemic risks and the need for vigilant ...

"That being said, receptor mutations alone don't guarantee that the virus will transmit between humans." Past cases in which avian viruses adapted to infect and transmit between people required ...