These macrophages were the most transcriptionally primed to launch an exosomal assault. To investigate the effects of foam cell exosomes, researchers generated them in a dish. They cultured bone ...

CD8+ T cells accumulate in atherosclerotic plaques. LMU researchers identify a crucial signaling pathway—with therapeutic ...

CD8+ T cells accumulate in atherosclerotic plaques. Researchers identify a crucial signaling pathway -- with therapeutic potential.

For a long time, macrophages and foam cells were considered the principal agents in the formation of plaques. More recent studies, however, have focused on other immune system cells, CD8+ T cells ...

Keywords: VSMCs, foam cell, atherosclerosis, ox-LDL, cholesterol metabolism Citation: Guo J and Du L (2024) An update on ox-LDL-inducing vascular smooth muscle cell-derived foam cells in ...

Macrophage foam cells produce cytokines that stimulate smooth muscle cell infiltration, which in turn promotes extracellular matrix production and fibrosis.

Cholesterol, essential for cells and hormones, balances LDL (bad) and HDL (good). Genetic factors, lifestyle, and conditions like diabetes affect heart health. Proper levels via diet, exercise, and ...

Nano-sized particles released by red blood cells reduce inflammation and fat deposition in immune cells, potentially paving the way for new methods of treating atherosclerosis ...

Cholesterol-overloaded cells or “foam cells” in the artery wall are the biochemical hallmark of atherosclerosis, and are responsible for much of the growth, inflammation and susceptibility to rupture ...

Atherosclerotic plaque consists of extracellular lipid particles, foam cells, and debris that have accumulated in the intima of the arterial wall and formed a lipid or necrotic core. The core is ...

For the first time, scientists have demonstrated that a type of immune cell expresses a protein that promotes the buildup of fatty material in arteries.