In this Thought Leader article., Ian Johnston from Cytiva discusses challenges related to process development, scaling technology, regulatory approvals, and GMP guidelines.

Endocytosis allows eukaryotic cells to remove signaling receptors ... from where cargo is either recycled back to the plasma membrane or sorted into the endo-lysosomal pathway for degradation.

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed -- for instance in ...

This research will interest cell biologists studying protein trafficking ... However, heterotrimer density on endocytic membranes is lower than on the plasma membrane, suggesting that G protein ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance in case ...

Few questions have captivated humankind more than the origin of life on Earth. How did the first living cells come to exist? How did these early protocells develop the structural membranes necessary ...

These membranes, composed of flexible lipid bilayers, can reshape and remodel themselves during processes like cell movement, division, and molecular trafficking. Until now, it was commonly assumed ...

The investigators studied the membrane-targeting sequence (MTS) of bactofilin A (BacA) in Caulobacter crescentus to explore its role in membrane binding and polymerization. They used various ...

For instance, the nucleus stores genetic material, and mitochondria produce energy. Another essential part of a cell is the membrane that encloses it. Proteins embedded on the surface of the membrane ...

LNPs carrying mRNA need to arrive at the cells, where they will be taken in through a process known as endocytosis. There, the cell breaks the LNP carrier, which allows the mRNA cargo to be released.