In a phosphorylation-dependent positive feedback loop, the cytidine deaminase AID amplifies the generation of double-strand DNA breaks, which shows it can also function downstream of deamination.

Protein called PAPPA found to be ‘common driver’ of ageing in many types of human cells, but it’s triggered by sirtuins, which are important for regulating metabolism, team says.

It was recently shown that APOBEC3G causes cytidine deamination of HIV-1 negative-strand DNA during the process of reverse ... Liu, H. et al. The Vif protein of human and simian immunodeficiency ...