Every living cell must interpret its genetic code—a sequence of chemical letters that governs countless cellular functions. A ...

Scientists at The Wistar Institute have discovered how a key protein from the Epstein-Barr virus (EBV), EBNA-LP, ...

If measured from beginning to end, the DNA in our cells is too long to fit into the cell's nucleus, explaining why it must be ...

A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.

The exponential replication system that the Joyce lab has developed was the culmination of years of work. The original catalyst was a ligase, R3C, whose parent was originally selected from a ...

DNA ligase seals nicks in dsDNA using chemical energy of the phosphoanhydride bond in ATP or NAD + and assistance of a divalent metal cofactor Mg 2+. Molecular details of ligase catalysis are ...

Linking together of DNA strands by DNA ligases is essential for DNA replication and repair. Since many therapies used to treat cancer act by causing DNA damage, there is growing interest in the ...