The replisome is a large protein complex that carries out DNA replication, starting at the replication origin. It contains several enzymatic activities, such as helicase, primase and DNA ...

Mitosis is the complex process in which duplicated chromosomes are condensed, segregated with the help of the mitotic spindle, and packaged in to daughter cell nuclei. Mitosis occurs in five ...

Linking together of DNA strands by DNA ligases is essential for DNA replication and repair. Since many therapies used to treat cancer act by causing DNA damage, there is growing interest in the ...

Glucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain ...

If measured from beginning to end, the DNA in our cells is too long to fit into the cell's nucleus, explaining why it must be ...

He and a colleague proved a theory advanced by the Nobel Prize winners James Watson and Francis Crick, who discovered DNA’s ...

Every living cell must interpret its genetic code—a sequence of chemical letters that governs countless cellular functions. A ...

Scientists at The Wistar Institute have discovered how a key protein from the Epstein-Barr virus (EBV), EBNA-LP, ...

New imaging tools reveal how within an hour of infection, the virus begins to alter our chromosomes to kick-start its own replication.

Enzymes are involved in virtually every biological process that occurs throughout the body. This includes but is not limited ...

Franklin W. Stahl, an American molecular biologist whose landmark 1957-58 experiment with colleague Matthew Meselson revealed ...

The Annual Ligase Targeting Drug Development Summit, now in its 4th year, will unite 80+ ligase experts dedicated to tackling ligase bottlenecks through data-driven presentations, technical ...