The replisome is a large protein complex that carries out DNA replication, starting at the replication origin. It contains several enzymatic activities, such as helicase, primase and DNA ...

TopBP1 plays a critical role in mitigating replication stress in cancer cells by recruiting the nuclease scaffold SLX4 to underreplicated DNA during mitosis, thereby promoting MiDAS and genome ...

Glucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain ...

He and a colleague proved a theory advanced by the Nobel Prize winners James Watson and Francis Crick, who discovered DNA’s ...

If measured from beginning to end, the DNA in our cells is too long to fit into the cell's nucleus, explaining why it must be ...

Every living cell must interpret its genetic code—a sequence of chemical letters that governs countless cellular functions. A ...

New imaging tools reveal how within an hour of infection, the virus begins to alter our chromosomes to kick-start its own replication.

Enzymes are involved in virtually every biological process that occurs throughout the body. This includes but is not limited ...

Scientists at The Wistar Institute have discovered how a key protein from the Epstein-Barr virus (EBV), EBNA-LP, ...

Franklin W. Stahl, an American molecular biologist whose landmark 1957-58 experiment with colleague Matthew Meselson revealed ...

The Annual Ligase Targeting Drug Development Summit, now in its 4th year, will unite 80+ ligase experts dedicated to tackling ligase bottlenecks through data-driven presentations, technical ...

Scientists studying ancient human remains uncovered in Colombia have found that the people they were researching have no known ancestors or modern descendants.