ZMYM1 binds to E-cadherin by recruiting the CRS site of the CtBP/LSD1/CoREST complex to the promoter, thereby inhibiting E-cadherin expression. It also promotes EMT and metastasis in GC cells (23).

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China With the ...

Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United ...