Engagement of the T cell receptor (TCR) in the absence of CD28 costimulation can result in a long-term hyporesponsive state called 'clonal anergy' 1. Anergic T cells have defective production of ...

Induction of T-cell clonal anergy involves serial activation of transcription factors, including NFAT and Egr2/3. However, downstream effector mechanisms of these transcription factors are not ...

Anergy occurs under several different circumstances, suggesting that T cells are poised to become anergic--presumably a protective response that helps limit immune reactions and prevent responses ...