For CD40L stimulation, a phosphospecific IκB-α antibody was used because complete cellular degradation of IκB-α was not noted in normal controls over a prolonged time-course experiment.

Effector CD4⁺ T cells restore antiviral CD8⁺ T cell function in the liver by licensing Kupffer cells via CD40–CD40L interactions. This triggers IL-27 production and reprograms the hepatic ...

Co-stimulation of CD40 also increased restored TLR9 induced proliferation of SLE B cells. As already reported, 93 the induction of CD27+CD38+ PB/PC was lower compared to TLR9 or TLR9/BCR stimulation.

Fc-Dependent Depletion of Activated T Cells Occurs Through CD40L-Specific Antibody Rather Than Costimulation Blockade ...

IRVINE, Calif., June 25, 2025 (GLOBE NEWSWIRE) -- Eledon Pharmaceuticals, Inc. (“Eledon”) (Nasdaq: ELDN) today announced that it will host an R&D Day in New York City on Wednesday, July 9, 2025 ...

Hopes rise for a new treatment option for people living with lupus, after UCB and Biogen reveal phase 3 data with their anti-CD40L antibody DZP.

Explore the latest advances in immunosuppression research that may bring transplant patients closer to the goal of having "one organ for life". Learn about new developments in organ transplant and ...

Sensory Stimulation Systems, and GENUS, refer to a noninvasive procedure, i.e., a "digital therapeutic," being developed by Cognito Therapeutics. The company developed a wearable GammaSense ...

Here's what you need to know about the giving and getting of oral sex, plus all of the fun and even practical stuff in between.

Clitoral atrophy happens when there's a loss of blood flow to the clitoris. Learn the causes, symptoms, and treatment options.

Read about Tonix Pharmaceuticals Holding Corp (TNXP:XNAS) stock and today's latest news and financial updates.

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