Biosynthetic pathways for secondary metabolites usually make many products, not just one. In this Commentary, we consider why molecular promiscuity might be an evolutionarily advantageous feature ...

Overrepresentation and pathway analyses highlighted branched-chain amino acids and ... in metabolite sets relevant for protein biosynthesis with particular impact on the aminoacyl-tRNA ...

The pyrimidine biosynthetic pathway is tightly regulated to ensure the proper balance ... These compounds inhibit the enzyme acetolactate synthase (ALS), which is crucial for the synthesis of branched ...