Introduction Individualised treatment through therapeutic drug monitoring (TDM) may improve tuberculosis (TB) treatment outcomes but is not routinely implemented. Prospective clinical studies of drug ...

Objective To determine if urinary lipoarabinomannan (LAM) may serve as a biomarker to monitor antituberculosis (TB) therapy response, and whether LAM results before and after treatment are predictive ...

Its biological properties as a potential antituberculosis agent and novel molecular architecture elevated it to an opportunistic target molecule.

Two international clinical studies led by PD Dr Norbert Heinrich at the Institute of Infectious Diseases and Tropical Medicine at LMU University Hospital Munich with international partners have shown ...

Florasulam Is a Potent Inhibitor of Mycobacterium tuberculosis Acetohydroxyacid Synthase and Possesses In Vivo Antituberculosis Activity Shun Jie Wun , Lendl Tan , Thierry G. Lonhienne , Yu Shang Low ...

Histone deacetylase (HDAC) impairment is strongly related to various cancers as well as neurodegenerative and inflammatory diseases. Considering HDACs’ crucial role as drug targets, over the past ...