Studies using high-fat diet (HFD)-fed adipocyte-specific Fas knockout mice have shown a dual impact: reduced inflammation and ...

A research team has identified an essential mechanism in fat cells (adipocytes) that enables them to enlarge safely to store ...

Researchers at Osaka University have identified ARMC5 as a key regulator of fatty acid balance in adipose tissue. ARMC5 ...

As part of this work, they have used mice to study metabolic adaptations that drive thermogenesis in adipocytes. Guertin noted that brown adipose tissue is a key factor in energy balance ...

When metabolic endotoxemia was induced for 4 weeks in mice through continuous subcutaneous infusion of LPS, fasted glycemia and insulinemia and whole-body, liver, and adipose tissue weight gain ...

Unlike white adipose tissue, which stores excess calories consumed, brown and beige adipocytes play a metabolically beneficial role by using stored fat to release heat. In the laboratory of ...

Researchers from Adipo Therapeutics LLC presented data from preclinical studies that aimed to assess the γ-secretase inhibitor ADPO-002 (dibenzazepine) for the treatment of obesity.

Obesity is an increasingly prevalent human condition in developed societies. Despite major progress in the understanding of the molecular mechanisms leading to obesity, no safe and effective ...

Researchers at Osaka University identified a degradation factor for SREBP1 as essential for maintaining the balance of ...